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The Five-Step Process
for Creating Sucralose (Splenda®)
Splenda® International Patent A23L001:
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Sucrose is tritylated with trityl chloride in the presence of
dimethylformamide and 4-methylmorpholine, and the tritylated sucrose
is then acetylated with acetic anhydride.
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The resulting sucrose molecule TRISPA (6,1’,6’-tri-O-trityl-penta-O-acetylsucrose)
is chlorinated with hydrogen chlorine in the presence of toluene.
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The resulting 4-PAS (sucrose 2,3,4,3’,4’-pentaacetate)
is heated in the presence of methyl isobutyl ketone and acetic acid.
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The resulting 6-PAS (sucrose 2,3,6,3’,4’-pentaacetate)
is chlorinated with thionyl chloride in the presence of toluene
and benzyltriethlyammonium chloride.
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The resulting TOSPA (sucralose pentaacetate) is treated with methanol
in the presence of sodium methoxide to produce sucralose.
Reference: The Chemical Abstracts Service Registry number for sucralose:
56038-13-2. http://www.cas.org/
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