Splenda Studies


 

Dental Decay  
Food labeling: health claims; dietary noncariogenic carbohydrate sweeteners and dental caries. Final rule
Dental considerations in sucralose use.
Action of agents on glucosyltransferases from Streptococcus mutans in solution and adsorbed to experimental pellicle
Noncariogenic intense natural sweeteners.
Effect of sucralose--alone or bulked with maltodextrin and/or dextrose--on plaque pH in humans
Effect of sucralose in coffee on plaque pH in human subjects.
Effect of aqueous solutions of sucralose on plaque pH
[Clastogenic activity of dietary sugar substitutes]
The effects of sucralose, xylitol, and sorbitol on remineralization of caries lesions in rats
The effects of sucralose on coronal and root-surface caries.
The influence of sucralose on bacterial metabolism.
Influence of sweetening agents in solution on dental caries in desalivated rats
High-potency sweeteners and dental health.
The effect of sweeteners on acid production in plaque
Comparative effects of five chlorosucrose analogues on acidogenicity and adherence of the oral bacterium Streptococcus mutans in vitro
Comparative effects of the substance-sweeteners glucose, sorbitol, sucrose, xylitol and trichlorosucrose on lowering of pH by two oral Streptococcus mutans strains in vitro
Effects of two potential sucrose-substitute sweetening agents on deposition of an oral streptococcus on glass in the presence of sucrose.

 

Taste of Sucralose Top
The intake of intense sweeteners - an update review.
Female rats show a bimodal preference response to the artificial sweetener sucralose.
Oral zinc sulfate solutions inhibit sweet taste perception.
Acetaminophen-containing chewable tablets with suppressed bitterness and improved oral feeling
Whole nerve chorda tympani responses to sweeteners in C57BL/6ByJ and 129P3/J mice
Sweetener preference of C57BL/6ByJ and 129P3/J mice
Effect of temperature, pH, and ions on sweet taste
Effect of storage on the flavours of cola drinks sweetened with different sweetener systems.
Sugar substitutes. Americans opt for sweetness and lite.
Bitterness of sweeteners as a function of concentration

 

Review Top
Artificial sweeteners--do they bear a carcinogenic risk?
Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners.
Acute and subchronic toxicity of sucralose.
Sucralose--an overview of the toxicity data.
I understand there is a new artificial sweetener on the market. Is it any safer than others
Sucralose--a new artificial sweetener
A new substitute for sugar.
The development and applications of sucralose, a new high-intensity sweetener.
Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners.
Review of present and future use of nonnutritive sweeteners.
Renal mineralization--a ubiquitous lesion in chronic rat studies
Long-term food consumption and body weight changes in neotame safety studies are consistent with tmetric relationship observed for other sweeteners and during dietary restrictions.

 

Humans Top
Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes
Sweeteners and beta-glucans improve metabolic and anthropometrics variables in well controlled type 2 diabetic patients
Repeated dose study of sucralose tolerance in human subjects.
Sucralose metabolism and pharmacokinetics in man.
Migraine triggered by sucralose--a case report.
Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes

 

Animals Top
The metabolic fate of sucralose in rats
The pharmacokinetics and metabolism of sucralose in the rabbit.
The pharmacokinetics and metabolism of sucralose in the mouse
The pharmacokinetics and metabolism of sucralose in the dog.
A carcinogenicity study of sucralose in the CD-1 mouse.
A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats.
Sucralose: assessment of teratogenic potential in the rat and the rabbit.
Sucralose: lack of effects on sperm glycolysis and reproduction in the rat.
Neurotoxicity studies on sucralose and its hydrolysis products with special reference to histopathologic and ultrastructural changes.
Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay.

 

Assay of sucralose directly or sucralose used as an assay Top
[Analysis of nine kinds of sweeteners in foods by LC/MS]
A simple method for the analysis of urinary sucralose for use in tests of intestinal permeability.
Experimental design-based development and single laboratory validation of a capillary zone electrophoresis method for the determination of the artificial sweetener sucralose in food matrices
Evaluation of a triple sugar test of colonic permeability in humans.
Determination of sucralose in Splenda and a sugar-free beverage using high-performance anion-exchange chromatography with pulsed amperometric detection.
Determination of the artificial sweetener Sucralose by capillary electrophoresis
In vivo influence of nicotine on human basal and NSAID-induced gut barrier function.
[Determination of sucralose in foods by HPLC using pre-column derivatization]
[Determination of sucralose in foods by liquid chromatography/tandem mass spectrometry
Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography
Gas chromatographic method for detection of urinary sucralose: application to the assessment of intestinal permeability
4,1',6'-Trichloro-4,1',6'-trideoxysucrose monohydrate.
The comet assay with 8 mouse organs: results with 39 currently used food additive
Two halodeoxy sucrose analogues.
Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs.
[Determination of sucralose in foods by HPLC]
Determination of sucralose in foods by anion-exchange chromatography and reverse-phase chromatography]
A minisensor for the rapid screening of sucralose based on surface-stabilized bilayer lipid membranes.
Localization and quantification of hydrophobicity: the molecular free energy density (MolFESD) concept and its application to sweetness recognition.
Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease
Review article: Intestinal permeability in Crohn's disease.
Tin(IV)-functionalised polymer supports; non-toxic and practical reagents for regioselective acetylation of sucrose.
Conformational analysis of disaccharides using molecular dynamics and NMR methods.
Microbial cometabolism of sucralose, a chlorinated disaccharide, in environmental samples.
Cyclic acetals of 4,1',6'-trichloro-4,1',6'-trideoxy-galacto-sucrose and their conversion into methyl ether derivatives.
Determination of seven artificial sweeteners in diet food preparations by reverse-phase liquid chromatography with absorbance detection.
Relationship between the structure and the properties of carbohydrates in aqueous solutions: sweetness of chlorinated sugars
Resolution of common dietary sugars from probe sugars for test of intestinal permeability using capillary column gas chromatography.


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